Interaction of surfactants with poloxamers 338 and its effect on some properties of cream base

The aim. Study of the interaction surfactants with poloxamer 338 (P338) and effect P338 on properties cream bases.
 Materials methods. Solutions as well bases were under study. average hydrodynamic diameter (Dh) zeta potential (ζ‑potential) determined by light scattering intensity electrophoretic mobility micelles. electron paramagnetic resonance (EPR) spectra spin probes in micelles, solvents obtained; type spectrum, isotropic constant (AN), rotational correlation times (τ) anisotropy parameter (ε) determined. Liquids studied capillary viscometry; flow behaviour yield stress (t0), dynamic apparent viscosity (η) hysteresis (thixotropic) area (AH) microstructure was examined optical microscopy. strength adhesion (Sm) assessed pull-off test, absorption water dialysis.
 Results. Under impact diameters micelles formed cationic, anionic nonionic decreased absolute values their ζ‑potential became lower, but microviscosity micelle nuclei increased. There also a change structure aggregates surfactant fatty alcohols; EPR spectra, which superpositions characteristic for lateral phase separation, converted into triplets that indicated uniform distribution lipophilic phase. When content increased to 17 %, rheological parameters drastically, changed. had consistency within temperature range from 25 °C 70 completely restored viscosity, shear stress. enhances adhesive bases. Due microstructure, have lower ability absorb compared solution gel containing % 20 P338, respectively.
 Conclusions. alcohols changed due P338. As result this interaction, at sufficiently high concentration changed, parameters, remain temperatures °C, significantly, decreased. more